ITDOL TH4

Aceclofenac is a proven effective well tolerated NSAID provides sustained pain relief by preferentially blocking COX (Cyclo-oxygenase) II enzyme, with good GI tolerability compared to other selective COX-2 inhibitors. A GABA-A antagonist,semi-synthetic colchicoside (natural compound) derivative, A centrally acting muscle relaxant. Thiocolchicide is a GABA-A recptor antagonist,which binds to GABA-A and strychnine sensitive glycine receptors.This results the reduction of spasticity.It also has myorelaxant effects at the supraspinal level, via complex regulatory mechanisms.