Benfotiamine (IH)

Benfotiamine is a dietary supplement, and it contains vitamin B1. Benfotiamine helps to prevent harmful by-products of glucose metabolism and reduce oxidative stress leading to improved endothelial function. Unlike thiamine salts, Benfotiamine is more bioavailable and provides higher levels of Thiamine in major organs such as the muscle, brain, liver, and kidney. It is due to the dephosphorylation of Benfotiamine to S-benzoyl Thiamine by alkaline phosphatases in the intestinal mucosa and subsequent hydrolysis to Thiamine by thioesterases in the liver. Additionally, Benfotiamine mainly acts on peripheral tissues through an increased transketolase activity.