Reduces vertebral fractures by up to 68% and hip fractures by 40%.
No renal dose adjustments required.
Description
Masden — Denosumab 60 mg/ml RANKL Inhibitor (IgG2). Blocks RANKL–RANK interaction, preventing osteoclast formation. Reduces vertebral fractures by up to 68% and hip fractures by 40% (FREEDOM study). No renal dose adjustments required.
Mechanism
Blocks RANKL–RANK interaction, preventing formation, function, and survival of osteoclasts. Decreases cortical & trabecular bone resorption. Increases BMD at hip, lumbar spine, and femoral neck.
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